Yes, you can control who comments on your Facebook posts, but the options differ slightly for personal profiles and pages. On a personal profile, you can’t completely turn off comments for all friends, but you can limit who can comment by clicking the three dots on your post, selecting “Who can comment on your post?”, and choosing either Friends or Profiles and Pages you mention. For Facebook Pages, you have more control: go to Settings → General → Visitor Posts or adjust comment moderation settings for individual posts to restrict or hide comments. This way, you can manage interactions without fully disabling the post.